Abstract
Ternifolide A (1), a new diterpenoid featuring a unique 10-membered lactone ring formed between C-6 and C-15, along with ternifolide B (2), a nor-diterpenoid, and ternifolide C (3) were isolated from the leaves of Isodon ternifolius. Both H-8 and H-9 being α-orientations in compound 1 were found for the first time. The absolute configurations of 1 and 3 were confirmed by X-ray diffraction study. Compounds 1 and 3 were evaluated for their cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cell Survival / drug effects
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Humans
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Isodon / chemistry*
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Macrolides / chemistry*
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Models, Molecular
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Molecular Conformation
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Plant Leaves / chemistry
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Terpenes / chemistry*
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Terpenes / isolation & purification
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Terpenes / pharmacology
Substances
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Diterpenes
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Macrolides
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Terpenes
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ternifolide A