Single-nucleotide polymorphisms in inflammatory bowel disease

Manuela G Neuman; Radu M Nanau

doi:10.1016/j.trsl.2011.10.006

Single-nucleotide polymorphisms in inflammatory bowel disease

Transl Res. 2012 Jul;160(1):45-64. doi: 10.1016/j.trsl.2011.10.006. Epub 2011 Nov 23.

Authors

Manuela G Neuman¹, Radu M Nanau

Affiliation

¹ Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, and In Vitro Drug Safety and Biotechnology, MaRS, Toronto, Ontario, Canada. manuela.neuman@utoronto.ca

PMID: 22687962
DOI: 10.1016/j.trsl.2011.10.006

Abstract

Strong evidence indicates that inflammatory bowel disease, including Crohn disease and ulcerative colitis, is a result of an inappropriate inflammatory response in which genetic and environmental factors play important roles. This review discusses several single-nucleotide polymorphisms with either susceptibility or protective effects on inflammatory bowel disease.

Publication types

Review

MeSH terms

CARD Signaling Adaptor Proteins / genetics
Carrier Proteins / genetics
Cell Differentiation / genetics
Genes, MHC Class II
Genetic Predisposition to Disease
Humans
Inflammatory Bowel Diseases / genetics*
Phagosomes / genetics
Polymorphism, Single Nucleotide*
Proteasome Endopeptidase Complex / genetics
Receptors, Interleukin / genetics
Translational Research, Biomedical
Tumor Necrosis Factor-alpha / genetics

Substances

CARD Signaling Adaptor Proteins
Carrier Proteins
Receptors, Interleukin
Tumor Necrosis Factor-alpha
Proteasome Endopeptidase Complex