Abstract
Limited comprehensive molecular typing data exist currently for Panton-Valentine leucocidin (PVL)-positive, methicillin-sensitive Staphylococcus aureus (PVL-MSSA) clinical isolates. Characterization of PVL-MSSA isolates by multilocus sequence typing (MLST) and spa typing in this study showed a genetic similarity to PVL-positive, methicillin-resistant S. aureus (PVL-MRSA) strains, although three novel spa types and a novel MLST (ST1518) were detected. Furthermore, the detection of PVL phages and haplotypes in PVL-MSSA identical to those previously found in PVL-MRSA isolates highlights the role these strains may play as precursors of emerging lineages of clinical significance.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Bacterial Toxins / genetics*
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Child
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Child, Preschool
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Community-Acquired Infections / microbiology*
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Exotoxins / genetics*
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Female
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Haplotypes
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Humans
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Infant
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Infant, Newborn
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Leukocidins / genetics*
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Male
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Methicillin / pharmacology
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Microbial Sensitivity Tests
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Middle Aged
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Molecular Epidemiology
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Molecular Typing*
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Prophages / genetics
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Staphylococcal Infections / microbiology*
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Staphylococcus Phages / genetics
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Staphylococcus aureus / classification*
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Staphylococcus aureus / genetics*
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Staphylococcus aureus / isolation & purification
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Virulence Factors / genetics*
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Young Adult
Substances
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Bacterial Toxins
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Exotoxins
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Leukocidins
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Panton-Valentine leukocidin
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Virulence Factors
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Methicillin