A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity

Angew Chem Int Ed Engl. 2012 Aug 6;51(32):8110-3. doi: 10.1002/anie.201202090. Epub 2012 Jul 3.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • HIV-1 / drug effects*
  • Humans
  • Ligands
  • Models, Molecular
  • Molecular Conformation
  • Peptoids / chemistry*
  • Peptoids / pharmacology*
  • Receptors, CXCR4 / agonists
  • Receptors, CXCR4 / metabolism*
  • Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • CXCR4 protein, human
  • Ligands
  • Peptoids
  • Receptors, CXCR4