[Cutaneous drug eruption at hospital in Bamako]

Mali Med. 2012;27(1):57-61.
[Article in French]

Abstract

Introduction: The incidences of cutaneous drug eruption constitute a real public health problem.

Objective: The aim of this study was to describe the cutaneous drug eruption in Gabriel Touré Hospital in Bamako.

Material and method: This is a prospective longitudinal study from 1 July 2005 to August 31, 2006. The study included patients with a lesion cutaneous Contemporary taking medication, without other cause and consent.

Results: We included 61 cases of toxdermies. The mean age was 28 ± 14.8 years with extremes of 18 and 77 years. The sex ratio was 2.4 for women. Self-medication was most often found in 51% of cases. The fixed drug eruption (EPF) with 26 cases (30.6%); acne with 23 cases (27%), erythema multiforme with 14 cases (16.5%) are the predominant manifestations toxidermy. The causative drugs are molecules with 12.6% with analgesics, NSAIDs with 12.6%, 13.6% with ARVs; sulfonamides with 9.5% with 7.4% beta-lactam; anticonvulsants with 5.2%. The therapeutic management was simple for minor forms. Severe forms have been hospitalized and often the help of intensive care and ophthalmology. Mortality was 2.3%.

Conclusion: The toxidermy exist in Mali with a frequency more and more increasing. We recommend the systematic toxidermy consultations especially among HIV patients in Mali.

Publication types

  • English Abstract

MeSH terms

  • Acne Vulgaris / chemically induced
  • Acne Vulgaris / epidemiology
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anticonvulsants / adverse effects
  • Drug Eruptions / epidemiology*
  • Drug Eruptions / etiology
  • Erythema Multiforme / epidemiology
  • Female
  • Hospitals, University / statistics & numerical data
  • Humans
  • Male
  • Mali / epidemiology
  • Middle Aged
  • Morbidity / trends
  • Prospective Studies
  • Self Medication / adverse effects
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants