Abstract
A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antidepressive Agents / chemical synthesis*
-
Antidepressive Agents / chemistry
-
Cyclopropanes / chemical synthesis*
-
Cyclopropanes / chemistry*
-
Milnacipran
-
Phenylacetates / chemical synthesis
-
Phenylacetates / chemistry
-
Stereoisomerism
Substances
-
Antidepressive Agents
-
Cyclopropanes
-
Phenylacetates
-
cyclopropane
-
phenylacetic acid
-
Milnacipran