Consistency of standard laboratory strain Mycobacterium tuberculosis H 37 Rv with ethionamide susceptibility testing

R Lakshmi; Vanaja Kumar; Fathima Rahman; Ranjani Ramachandran

Consistency of standard laboratory strain Mycobacterium tuberculosis H 37 Rv with ethionamide susceptibility testing

Indian J Med Res. 2012 May;135(5):672-4.

Authors

R Lakshmi¹, Vanaja Kumar, Fathima Rahman, Ranjani Ramachandran

Affiliation

¹ Department of Bacteriology, National Institute for Research in Tuberculosis (ICMR), Chennai, India.

PMID: 22771598
PMCID: PMC3401699

Abstract

Drug susceptibility pattern of standard Mycobacterium tuberculosis strain H 37 Rv showed discrepancy in minimum inhibitory concentration method for ethionamide and consistent results were obtained for the other second line drugs namely, kanamycin and ofloxacin. It is, therefore, necessary to revisit the susceptibility testing method for ethionamide for effective clinical management of patients with drug resistant tuberculosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance, Microbial
Ethionamide / pharmacology*
Humans
Kanamycin / pharmacology*
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Mycobacterium tuberculosis / pathogenicity
Ofloxacin / pharmacology*
Tuberculosis, Multidrug-Resistant / drug therapy*
Tuberculosis, Multidrug-Resistant / microbiology

Substances

Kanamycin
Ofloxacin
Ethionamide