Hypoglycemic effects of hyaluronate-endo-β-N-acetylhexosaminidase immobilized by electron beam synthesis nanotechnology

A M Dygai; G N Zyuz'kov; V V Zhdanov; E V Udut; L A Miroshnichenko; T J Khrichkova; E V Simanina; L A Stavrova; R V Gurto; M Yu Minakova; A V Chajkovskij; T S Markova; A V Artamonov; A A Bekarev; P G Madonov; D N Kinsht

doi:10.1007/s10517-012-1652-5

Hypoglycemic effects of hyaluronate-endo-β-N-acetylhexosaminidase immobilized by electron beam synthesis nanotechnology

Bull Exp Biol Med. 2012 May;153(1):94-7. doi: 10.1007/s10517-012-1652-5.

Authors

A M Dygai¹, G N Zyuz'kov, V V Zhdanov, E V Udut, L A Miroshnichenko, T J Khrichkova, E V Simanina, L A Stavrova, R V Gurto, M Yu Minakova, A V Chajkovskij, T S Markova, A V Artamonov, A A Bekarev, P G Madonov, D N Kinsht

Affiliation

¹ Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru

PMID: 22808503
DOI: 10.1007/s10517-012-1652-5

Abstract

Hypoglycemic effect of hyaluronate-endo-β-N-acetylhexosaminidase immobilized by electron-beam synthesis nanotechnology (imHEA-HA) was studied in experimental insulin-dependent and insulin-independent diabetes mellitus. The drug exhibited a hypoglycemic effect of its own and potentiated the pharmacological effect of exogenous insulin injected in vivo. Studies on liver cell culture demonstrated an increase of cell sensitivity to insulin after treatment with imHEA-HA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Diabetes Mellitus / drug therapy
Enzymes, Immobilized / therapeutic use*
Glycosaminoglycans / chemistry*
Hyaluronoglucosaminidase / metabolism
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / therapeutic use*
Mice
Nanotechnology / methods*
beta-N-Acetylhexosaminidases / chemistry*
beta-N-Acetylhexosaminidases / therapeutic use*

Substances

Enzymes, Immobilized
Glycosaminoglycans
Hypoglycemic Agents
Hyaluronoglucosaminidase
beta-N-Acetylhexosaminidases