The effect of toll-like receptor 4 on macrophage cytokines during endotoxin induced uveitis

Int J Mol Sci. 2012;13(6):7508-7520. doi: 10.3390/ijms13067508. Epub 2012 Jun 18.

Abstract

Toll-like receptor 4 (TLR4) signal activation of macrophages can lead to endotoxin-induced uveitis (EIU). Previously, our research group has demonstrated a higher expression of TLR4 in vivo during EIU than normal. In this study, we analyzed levels of peritoneal macrophage cytokines from C3H/HeN mice with LPS stimulation in vitro to elucidate the effect of TLR4 on cytokines during EIU.

Keywords: Toll-like receptor 4; cytokine; endotoxin-induced uveitis; mice peritoneal macrophage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Lipopolysaccharides / toxicity*
  • Macrophages, Peritoneal / immunology*
  • Macrophages, Peritoneal / pathology
  • Male
  • Mice
  • Monokines / immunology*
  • Toll-Like Receptor 4 / immunology*
  • Uveitis / chemically induced*
  • Uveitis / immunology*
  • Uveitis / pathology

Substances

  • Lipopolysaccharides
  • Monokines
  • Tlr4 protein, mouse
  • Toll-Like Receptor 4