Abstract
During the 1990s, an epidemic of B:4 Neisseria meningitidis infections affected Brazil. Subsequent increase in C:4 disease suggested B → C capsular switching. This study identified B → C switches within the sequence type 32 complex. Substantial disease related to capsular switching emphasizes the need for surveillance of circulating meningococcal strains to optimize disease control.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antigenic Variation / genetics*
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Bacterial Capsules / genetics*
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Brazil / epidemiology
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Child
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Child, Preschool
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Epidemics*
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Female
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Genotype
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Humans
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Infant
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Male
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Meningococcal Infections / epidemiology
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Middle Aged
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Multilocus Sequence Typing
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Neisseria meningitidis, Serogroup B / classification
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Neisseria meningitidis, Serogroup B / genetics*
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Neisseria meningitidis, Serogroup C / classification
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Neisseria meningitidis, Serogroup C / genetics*
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Sequence Analysis, DNA
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Serotyping
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Young Adult