Greasing the way: the ABCs of HSPC efflux from the marrow

Abstract

In this issue of Cell Stem Cell, Westerterp et al. demonstrate that cholesterol flux through splenic phagocytes regulates hematopoietic stem and multipotential progenitor cell mobilization from the bone marrow. These exciting findings suggest new avenues for therapy of myeloproliferative disorders and atherosclerosis.