Abstract
We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their anticancer activity in cell culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemical synthesis
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Camptotheca / chemistry*
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Camptothecin / analogs & derivatives*
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Camptothecin / chemical synthesis
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Camptothecin / pharmacology
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Camptothecin / therapeutic use*
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Cell Line, Tumor
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Leukemia L1210 / drug therapy*
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Phytotherapy*
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Plant Extracts / chemical synthesis
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Treatment Outcome
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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10-hydroxycamptothecin
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Camptothecin