Recurrent bilateral metatarsal "stress-and-insufficiency" fractures in a levodopa-treated young woman with Parkinson's disease

Osteoporos Int. 2013 Mar;24(3):1131-3. doi: 10.1007/s00198-012-2104-9. Epub 2012 Aug 9.

Abstract

Levodopa treatment of Parkinson's disease is very effective, but many types of adverse events can complicate the disease course, especially dyskinesias. As reported by Lee et al. (Calcif Tissue Int 86:132-41, 2010), levodopa intake is associated with increased homocysteinemia that is known to be linked to poorer bone quality and, consequently, osteoporotic fractures. Herein, we report the case of a young woman who suffered recurrent metatarsal fractures in the context of levodopa-treated early-onset Parkinson's disease.

Publication types

  • Case Reports

MeSH terms

  • Antiparkinson Agents / adverse effects*
  • Antiparkinson Agents / therapeutic use
  • Dyskinesia, Drug-Induced / etiology
  • Female
  • Fractures, Stress / chemically induced*
  • Fractures, Stress / diagnostic imaging
  • Humans
  • Levodopa / adverse effects*
  • Levodopa / therapeutic use
  • Metatarsal Bones / diagnostic imaging
  • Metatarsal Bones / injuries*
  • Middle Aged
  • Osteoporotic Fractures / chemically induced
  • Osteoporotic Fractures / diagnostic imaging
  • Parkinson Disease / drug therapy*
  • Radiography
  • Recurrence

Substances

  • Antiparkinson Agents
  • Levodopa