[Bipolar disorder: a multifactorial disease]

Rev Med Liege. 2012 May-Jun;67(5-6):366-73.
[Article in French]

Abstract

Bipolar disorder is a multifactorial disease with a strong genetic component. However, environmental factors also play a role in the onset of the disease and in manic and depressive recurrence. The onset of the disorder is the consequence of a complex interaction between genetic and environmental factors. This gene-environment interaction is well illustrated by the influence of childhood trauma on the clinical expression of the disease in terms of age of onset, comorbidity and suicide. The complexity and heterogeneity of bipolar disorder require the identification of homogenous sub-groups with the use of biomarkers that could help reduce the etiological heterogeneity and better target the therapeutical options.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Bipolar Disorder / epidemiology*
  • Bipolar Disorder / etiology*
  • Bipolar Disorder / genetics
  • Bipolar Disorder / therapy
  • Causality
  • Disease Susceptibility
  • Environment
  • Gene-Environment Interaction
  • Humans
  • Risk Factors