Intracellular self-assembly of nanoparticles for enhancing cell uptake

Qingqing Miao; Xiaoyu Bai; Yingying Shen; Bin Mei; Jinhao Gao; Li Li; Gaolin Liang

doi:10.1039/c2cc34899c

Intracellular self-assembly of nanoparticles for enhancing cell uptake

Chem Commun (Camb). 2012 Oct 9;48(78):9738-40. doi: 10.1039/c2cc34899c.

Authors

Qingqing Miao¹, Xiaoyu Bai, Yingying Shen, Bin Mei, Jinhao Gao, Li Li, Gaolin Liang

Affiliation

¹ CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, P. R. China.

PMID: 22914507
DOI: 10.1039/c2cc34899c

Abstract

A radioactive probe (1) has been developed and applied to a condensation reaction and self-assembly of radioactive nanoparticles (i.e., (125)I-NPs) intracellularly. Upon 160 min cellular efflux, the radioactivity retained in cells incubated with 1 was 4-fold more higher than that of those cells treated with a scrambled control probe (1-Scr).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzothiazoles / chemical synthesis
Benzothiazoles / chemistry
Benzothiazoles / pharmacokinetics*
Humans
Iodine Radioisotopes
Molecular Structure
Nanoparticles / chemistry*
Neoplasms / diagnostic imaging*
Neoplasms / pathology
Radionuclide Imaging

Substances

Benzothiazoles
Iodine Radioisotopes