Failure of early nasal continuous positive airway pressure in preterm infants of 26 to 30 weeks gestation

J Perinatol. 2013 Apr;33(4):297-301. doi: 10.1038/jp.2012.110. Epub 2012 Aug 30.

Abstract

Objective: To identify variables associated with early nasal continuous positive airway pressure (ENCPAP) failure in preterm neonates less than 30 weeks gestational age.

Study design: Multicenter prospective study including 131 preterm newborns, over a period of 2 years. Patients and respiratory variables were assessed using univariate analysis.

Result: Variables associated with ENCPAP failure were: the need of resuscitation with a FiO(2)>0.30; a CPAP pressure of 6.4±1.2 cm H(2)O; the need of a FiO(2) of 0.40 in the first 4 h of life; male gender maintaining the need of a FiO(2)>0.25 in the first 4 h of life; and respiratory distress syndrome with criteria for surfactant administration.

Conclusion: The need for oxygen in resuscitation and maintained in first hours of life, male gender, a CPAP pressure over 5 cm H(2)O and surfactant need are predictors of ENCPAP failure in preterm neonates 26 to 30 weeks gestational age.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Confounding Factors, Epidemiologic
  • Continuous Positive Airway Pressure* / adverse effects
  • Continuous Positive Airway Pressure* / methods
  • Continuous Positive Airway Pressure* / statistics & numerical data
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Intensive Care, Neonatal / methods
  • Male
  • Outcome Assessment, Health Care
  • Oxygen / administration & dosage*
  • Prospective Studies
  • Pulmonary Surfactants / therapeutic use*
  • Respiratory Distress Syndrome, Newborn* / diagnosis
  • Respiratory Distress Syndrome, Newborn* / epidemiology
  • Respiratory Distress Syndrome, Newborn* / therapy
  • Resuscitation / methods*
  • Risk Factors
  • Sex Factors
  • Time Factors
  • Treatment Failure

Substances

  • Pulmonary Surfactants
  • Oxygen