Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins

V Kh Khavinson; N S Lin'kova; V O Polyakova; I M Kvetnoy; V V Benberin; M M D'yakonov; Yu S Titkov

doi:10.1007/s10517-012-1766-9

Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins

Bull Exp Biol Med. 2012 Aug;153(4):559-62. doi: 10.1007/s10517-012-1766-9.

[Article in English, Russian]

Authors

V Kh Khavinson¹, N S Lin'kova, V O Polyakova, I M Kvetnoy, V V Benberin, M M D'yakonov, Yu S Titkov

Affiliation

¹ I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

PMID: 22977870
DOI: 10.1007/s10517-012-1766-9

Abstract

Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis.

MeSH terms

Animals
Apoptosis / drug effects
Cell Proliferation / drug effects
Cells, Cultured
Cytoskeletal Proteins / metabolism*
Fibroblasts
Gene Expression Regulation / drug effects*
Image Processing, Computer-Assisted
Lamin Type A / genetics
Mice
Mice, Knockout
Microscopy, Fluorescence
Nuclear Matrix-Associated Proteins / metabolism*
Oligopeptides / pharmacology*

Substances

Cytoskeletal Proteins
Lamin Type A
Lmna protein, mouse
Nuclear Matrix-Associated Proteins
Oligopeptides