Lattice dynamics through the structural phase transition in D-amphetamine sulfate

J Phys Chem A. 2012 Oct 11;116(40):9854-62. doi: 10.1021/jp304843g. Epub 2012 Sep 27.

Abstract

The polarized infrared and Raman spectra of the single-crystalline D-amphetamine sulfate have been measured as a function of temperature in the vicinity of the structural phase transition. Infrared and Raman-active modes are identified and assigned. Significant signatures of the structural phase transition are observed in the temperature dependence of infrared modes both of the D-amphetamine unit and the sulfate anion. The changes reflect differences in the unit cell between low- and high-temperature phases of the D-amphetamine sulfate. Temperature dependence of the vibrational mode parameters displays pronounced hysteresis between 333 and 338 K that is extended over a smaller temperature range than 325-345 K found in the earlier DSC study.

MeSH terms

  • Crystallography, X-Ray
  • Dextroamphetamine / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Phase Transition
  • Spectrophotometry, Infrared
  • Spectrum Analysis, Raman
  • Thermodynamics*

Substances

  • Dextroamphetamine