Influenza A H1N1/2009 infection in pediatric solid organ transplant recipients

Transpl Infect Dis. 2012 Dec;14(6):584-8. doi: 10.1111/tid.12005. Epub 2012 Sep 24.

Abstract

Aim and method: The aim of this study was to describe the clinical characteristics and outcome of pandemic influenza A H1N1/2009 (pH1N1) infection, in a retrospective cohort of pediatric patients with kidney and/or liver transplant and confirmed pH1N1 infection from June to December 2009, diagnosed in 2 Spanish teaching hospitals.

Results: Forty-nine patients were included. Pneumonia was diagnosed in 4 patients (8.2%), and 3 of them required respiratory support. There were no related deaths.

Conclusion: Antiviral treatment within 48 h was associated with a lower likelihood of pneumonia (0/38, 0%) than treatment started after 48 h (4/11, 36.3%) (P < 0.01).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antiviral Agents / therapeutic use*
  • Child
  • Female
  • Humans
  • Immunocompromised Host
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human / epidemiology
  • Influenza, Human / prevention & control*
  • Influenza, Human / virology
  • Kidney Transplantation / adverse effects*
  • Liver Transplantation / adverse effects*
  • Male
  • Pandemics
  • Pneumonia / etiology
  • Retrospective Studies
  • Spain / epidemiology

Substances

  • Antiviral Agents