It takes 2 to thrombopoies in the vascular niche

Blood. 2012 Oct 4;120(14):2775-6. doi: 10.1182/blood-2012-07-435172.

Abstract

In this issue of Blood, Pitchford et al demonstrate that intravenous administration of VEGF-A promotes megakaryocyte (Mk) maturation and localization to bone marrow sinusoidal endothelial cells (BMECs), stimulating thrombopoiesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Blood Platelets / cytology*
  • Female
  • Megakaryocytes / cytology*
  • Placenta Growth Factor
  • Pregnancy Proteins / metabolism*
  • Receptors, CXCR4 / metabolism*
  • Vascular Endothelial Growth Factor A / metabolism*
  • Vascular Endothelial Growth Factor Receptor-1 / metabolism*
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism*

Substances

  • Pgf protein, mouse
  • Pregnancy Proteins
  • Receptors, CXCR4
  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, mouse
  • Placenta Growth Factor
  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factor Receptor-2