Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation

Brain Tumor Pathol. 2013 Jul;30(3):175-9. doi: 10.1007/s10014-012-0118-9. Epub 2012 Sep 28.

Abstract

A 63-year-old woman presented with dizziness followed by gait disturbance and loss of appetite. Magnetic resonance image (MRI) showed that a lesion located in the medulla oblongata, appearing as hyperintense on T2-weighted image and with slight enhancement area, appeared in the ventral aspect of the mass on T1-weighted MR imaging with gadolinium. It was diagnosed as high-grade brain-stem glioma and the patient underwent chemoradiotherapy. However, she died 18 days after treatment, and autopsy was performed. The pathological diagnosis was glioblastoma (GBM) with unmethylated O-6-methylguanine-DNA methyltransferase promoter and wild isocitrate dehydrogenase 1 gene. We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / therapy
  • Chemoradiotherapy
  • DNA Modification Methylases / genetics*
  • DNA Repair Enzymes / genetics*
  • Disease Progression
  • Fatal Outcome
  • Female
  • Glioblastoma / diagnosis
  • Glioblastoma / genetics*
  • Glioblastoma / pathology*
  • Glioblastoma / therapy
  • Humans
  • Isocitrate Dehydrogenase / genetics
  • Magnetic Resonance Imaging
  • Medulla Oblongata*
  • Methylation
  • Middle Aged
  • Mutation
  • Promoter Regions, Genetic / genetics*
  • Tumor Suppressor Proteins / genetics*

Substances

  • Tumor Suppressor Proteins
  • Isocitrate Dehydrogenase
  • DNA Modification Methylases
  • MGMT protein, human
  • DNA Repair Enzymes