Abstract
Peptide nucleic acid (PNA) inhibitors of miR-221-3p (CU-PNA-221) and miR-466l-3p (CU-PNA-466) demonstrated changes in inflammatory responses. Suppression of inflammatory signalling was unexpected and further investigation led to the identification of calmodulin as a novel target of miRNA-466l-3p. These studies demonstrate that exogenous agents may suppress neuroinflammation mediated by microglial cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology
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Base Sequence
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Calmodulin / antagonists & inhibitors
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Calmodulin / genetics
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Calmodulin / metabolism
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Cell Line
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Cell Survival / drug effects
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Humans
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Interleukin-10 / genetics
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Interleukin-10 / metabolism
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MicroRNAs / chemical synthesis
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MicroRNAs / chemistry*
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MicroRNAs / pharmacology
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Microglia / cytology
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Microglia / drug effects
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Nitric Oxide / metabolism
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Nitric Oxide Synthase Type II / genetics
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Nitric Oxide Synthase Type II / metabolism
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Peptide Nucleic Acids / chemistry*
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RNA, Messenger / metabolism
Substances
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Anti-Inflammatory Agents
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Calmodulin
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MicroRNAs
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Peptide Nucleic Acids
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RNA, Messenger
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Interleukin-10
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Nitric Oxide
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Nitric Oxide Synthase Type II