Rapid synthesis of oligomannosides with orthogonally protected monosaccharides

Chem Commun (Camb). 2013 May 14;49(39):4265-7. doi: 10.1039/c2cc37099a. Epub 2012 Nov 5.

Abstract

We developed a facile synthesis to yield orthogonally protected mannose building blocks with high overall yields. The protection/glycosylation steps can be carried out in a successive manner without purification of intermediate products. This developed synthesis led to formation of linear/branched tri-, penta- and heptasaccharides.

MeSH terms

  • Benzoic Acid / chemistry
  • Catalysis
  • Glycosylation
  • Hydrolysis
  • Monosaccharides / chemistry*
  • Oligosaccharides / chemical synthesis
  • Oligosaccharides / chemistry*
  • Pyridines / chemistry
  • Sulfonic Acids / chemistry

Substances

  • Monosaccharides
  • Oligosaccharides
  • Pyridines
  • Sulfonic Acids
  • oligomannoside
  • Benzoic Acid
  • pyridine