Advances in instrumentation have proceeded at an impressive rate since the invention of the electron microscope. These advances have produced a continuous expansion of the capabilities and range of application of electron microscopy. In order to provide some insights on how continuing advances may enhance cryo-electron microscopy and electron crystallography, we review some of the active areas of instrumentation development. There is strong momentum in areas including detectors, phase contrast devices, and aberration correctors that may have substantial impact on the productivity and expectations of electron crystallographers.