Polo boxes come out of the crypt: a new view of PLK function and evolution

Swadhin Chandra Jana; J Fernando Bazan; Mónica Bettencourt-Dias

doi:10.1016/j.str.2012.10.008

Polo boxes come out of the crypt: a new view of PLK function and evolution

Structure. 2012 Nov 7;20(11):1801-4. doi: 10.1016/j.str.2012.10.008.

Authors

Swadhin Chandra Jana¹, J Fernando Bazan, Mónica Bettencourt-Dias

Affiliation

¹ Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. sjana@igc.gulbenkian.pt

PMID: 23141691
DOI: 10.1016/j.str.2012.10.008

Abstract

Polo-like kinases (PLKs) are marked by C-terminal polo box modules with critical protein interaction and subcellular targeting roles. Slevin et al. in this issue of Structure reveal the architecture of a hidden set of polo boxes from the divergent PLK4, a critical player in centrosome duplication, shedding new light on the evolution of PLKs and their functionally related kinase ZYG-1.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Centrioles*
Humans
Protein Serine-Threonine Kinases / chemistry*

Substances

PLK4 protein, human
Protein Serine-Threonine Kinases