Circulating natriuretic peptide concentrations in hyperthyroid cats

J Small Anim Pract. 2012 Dec;53(12):673-8. doi: 10.1111/j.1748-5827.2012.01301.x. Epub 2012 Nov 12.

Abstract

Objectives: To assess the influence of thyroid function on natriuretic peptide concentration in hyperthyroid cats before and after treatment.

Methods: Serum natriuretic peptide concentration was measured in 61 hyperthyroid cats recruited from first-opinion clinics before and after treatment.

Results: Following successful treatment, total thyroxine, heart rate, systolic blood pressure and packed cell volume all decreased and bodyweight and creatinine concentrations increased. Furthermore, a significant (P < 0·001) decline in NT-proBNP concentration but not NT-proANP was identified.

Clinical significance: Thyroid function has a modest but significant effect on NT-proBNP concentration. Thyroid status should be taken into account when interpreting NT-proBNP concentrations in cats.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antithyroid Agents / therapeutic use
  • Biomarkers / blood
  • Blood Pressure / physiology
  • Case-Control Studies
  • Cat Diseases / blood*
  • Cat Diseases / drug therapy
  • Cats / blood*
  • Female
  • Heart Rate / physiology
  • Hyperthyroidism / blood
  • Hyperthyroidism / drug therapy
  • Hyperthyroidism / veterinary*
  • Male
  • Methimazole / therapeutic use
  • Natriuretic Peptide, Brain / blood
  • Natriuretic Peptides / blood*
  • Peptide Fragments / blood
  • Thyroxine / blood
  • Treatment Outcome

Substances

  • Antithyroid Agents
  • Biomarkers
  • Natriuretic Peptides
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • Methimazole
  • Thyroxine