Atypical chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids (CLIPPERS), primary angiitis of the CNS mimicking CLIPPERS or overlap syndrome? A case report

J Neurol Sci. 2013 Jan 15;324(1-2):183-6. doi: 10.1016/j.jns.2012.10.017. Epub 2012 Nov 11.

Abstract

A novel type of encephalomyelitis was first described as chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in 2010 and few additional patients were reported since then. Partially due to its unknown aetiology and a lack of pathognomonic features some have suggested that CLIPPERS may not represent a distinct disease, but rather a syndrome with different underlying aetiologies. Here we report a 49-year-old German female who presented with a number of clinical and paraclinical features described as typical for CLIPPERS, while additionally showing symptoms and findings compatible with primary angiitis of the CNS (PACNS). This case may establish a previously unnoted link between two poorly understood autoimmune conditions of the CNS.

MeSH terms

  • Brain / pathology
  • Cerebellum / pathology
  • Diagnosis, Differential
  • Diplopia / etiology
  • Encephalitis / diagnosis
  • Encephalitis / pathology
  • Encephalitis / physiopathology*
  • Female
  • Gait Disorders, Neurologic / etiology
  • Humans
  • Image Processing, Computer-Assisted
  • Lymphocytes / physiology*
  • Magnetic Resonance Imaging
  • Middle Aged
  • Pons / pathology
  • Vasculitis, Central Nervous System / diagnosis
  • Vasculitis, Central Nervous System / pathology
  • Vasculitis, Central Nervous System / physiopathology*