Drug reaction with eosinophilia and systemic symptoms (DRESS) in a patient taking sitagliptin

C Sin; E Mahé; M-L Sigal

doi:10.1016/j.diabet.2012.07.002

Drug reaction with eosinophilia and systemic symptoms (DRESS) in a patient taking sitagliptin

Diabetes Metab. 2012 Dec;38(6):571-3. doi: 10.1016/j.diabet.2012.07.002. Epub 2012 Nov 23.

Authors

C Sin¹, E Mahé, M-L Sigal

Affiliation

¹ Service de Dermatologie, Hôpital Victor-Dupouy, 69, rue du Lt-Col-Prud'hon, 95100 Argenteuil, France. carole.sin@ch-argenteuil.fr

PMID: 23183246
DOI: 10.1016/j.diabet.2012.07.002

Abstract

Sitagliptin is a recent oral antidiabetic drug for type 2 diabetes patients. This report is the first case of a severe drug reaction with eosinophilia and systemic symptoms (DRESS), which resolved with systemic corticosteroids. However, vigilance is necessary during the prescription of these compounds.

Publication types

Case Reports

MeSH terms

Acute Kidney Injury / chemically induced
Acute Kidney Injury / complications
Aged
Back / pathology
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / drug therapy*
Dipeptidyl-Peptidase IV Inhibitors / adverse effects*
Dipeptidyl-Peptidase IV Inhibitors / therapeutic use
Ear / pathology
Edema / chemically induced
Edema / pathology
Eosinophilia / chemically induced*
Eosinophilia / complications
Exanthema / chemically induced
Female
Glucocorticoids / administration & dosage
Humans
Prednisone / administration & dosage
Pyrazines / adverse effects*
Pyrazines / therapeutic use
Sitagliptin Phosphate
Triazoles / adverse effects*
Triazoles / therapeutic use

Substances

Dipeptidyl-Peptidase IV Inhibitors
Glucocorticoids
Pyrazines
Triazoles
Sitagliptin Phosphate
Prednisone