Abnormal GABA-mediated and cerebellar inhibition in women with the fragile X premutation

J Neurophysiol. 2013 Mar;109(5):1315-22. doi: 10.1152/jn.00730.2012. Epub 2012 Dec 12.

Abstract

The fragile X syndrome is a mutation-driven developmental disorder caused by a repetition over 200 times of the CGG trinucleotide situated in the 5'-untranslated region of the fragile X mental retardation 1 gene (FMR1). The interval between 55 and 199 CGG repeats, which is over the normal range but below full mutation, is named fragile X premutation. Recent studies have focused on the asymptomatic state of fragile X premutation carriers and their potentially relevant preclinical features. However, the underlying neurological mechanisms leading to altered functions in fragile X premutation carriers are still poorly understood. In this study, we wanted to test the hypothesis that asymptomatic women who carry the fragile X premutation present GABAergic and cerebellar abnormalities compared with healthy women without the premutation. We performed noninvasive brain stimulation protocols on both asymptomatic fragile X premutation carriers and controls comprising of measures of GABAA- and GABAB-mediated intracortical inhibition, afferent inhibition, and cerebello-motor functional interactions. Premutation carriers presented an absence of cerebellar inhibition over primary motor cortex as well as a reduced GABAA-mediated intracortical and afferent inhibition compared with healthy nonpremutated controls. These alterations are most probably dependent on a dysfunctional GABAergic mechanism associated with the fragile X premutation condition as previously found in CGG-repeat animal models. Furthermore, the lack of cerebello-motor inhibition could be related to the cerebellar structural abnormalities previously found in carriers of the premutation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Afferent Pathways / physiopathology
  • Asymptomatic Diseases
  • Case-Control Studies
  • Cerebellum / physiopathology*
  • Evoked Potentials, Motor
  • Female
  • Fragile X Mental Retardation Protein / genetics
  • Fragile X Syndrome / diagnosis
  • Fragile X Syndrome / genetics
  • Fragile X Syndrome / physiopathology*
  • GABAergic Neurons / metabolism
  • GABAergic Neurons / physiology
  • Humans
  • Middle Aged
  • Motor Cortex / physiopathology*
  • Mutation
  • Neural Inhibition*
  • Transcranial Magnetic Stimulation
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • FMR1 protein, human
  • Fragile X Mental Retardation Protein
  • gamma-Aminobutyric Acid