Chronic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease?

Drug Des Devel Ther. 2012:6:385-9. doi: 10.2147/DDDT.S37937. Epub 2012 Dec 10.

Abstract

Pulmonary eosinophilia comprises a heterogeneous group of diseases that are defined by eosinophilia in pulmonary infiltrates or in tissue. Drugs can cause almost all histopathologic patterns of interstitial pneumonias, such as cellular and fibrotic nonspecific interstitial pneumonia, pulmonary infiltrates and eosinophilia, organizing pneumonia, lymphocytic interstitial pneumonia, desquamative interstitial pneumonia, a pulmonary granulomatosis-like reaction, and a usual interstitial pneumonia-like pattern. We present a very rare case of chronic eosinophilic pneumonia due to radiographic contrast infusion diagnosed with video-assisted thoracoscopy. The patient after 1 year is still under corticosteroid treatment with the disease stabilized.

Keywords: interstitial lung disease; orphan disease; radiographic contrast.

Publication types

  • Case Reports

MeSH terms

  • Chronic Disease
  • Contrast Media / adverse effects*
  • Coronary Angiography / adverse effects
  • Coronary Angiography / methods
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use
  • Humans
  • Iohexol / adverse effects
  • Iohexol / analogs & derivatives*
  • Male
  • Middle Aged
  • Pulmonary Eosinophilia / chemically induced*
  • Pulmonary Eosinophilia / drug therapy
  • Pulmonary Eosinophilia / physiopathology
  • Thoracic Surgery, Video-Assisted

Substances

  • Contrast Media
  • Glucocorticoids
  • Iohexol
  • iopromide