Enantioselective homocrotylboration of aliphatic aldehydes

J Am Chem Soc. 2013 Jan 9;135(1):82-5. doi: 10.1021/ja311061n. Epub 2012 Dec 26.

Abstract

A practical route to optically pure syn-homocrotylation reagents is described, including highly diastereo- and enantioselective preparation of numerous syn-homocrotyl products, as well as several matched mismatched pairs. NMR experiments suggest that the active homocrotylating species is a cyclopropylcarbinyldichloroborane generated by chloride exchange from the PhBCl(2) activator. Computational studies support the intermediacy of chloroboranes and suggest that homoallyl/homocrotyl transfers occur through Zimmerman-Traxler transition states.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Boranes / chemical synthesis*
  • Boranes / chemistry
  • Molecular Structure
  • Quantum Theory
  • Stereoisomerism

Substances

  • Aldehydes
  • Boranes