Synthesis of multisubstituted pyridines

Org Lett. 2013 Jan 18;15(2):334-7. doi: 10.1021/ol303246b. Epub 2012 Dec 28.

Abstract

By utilizing amino allenes, aldehydes, and aryl iodides as readily available building blocks, a simple and modular synthesis of multisubstituted pyridines with flexible control over the substitution pattern has been achieved. The method employs a two-step procedure involving the preparation of "skipped" allenyl imines and a subsequent palladium-catalyzed cyclization.