Multi-object spring level sets (MUSCLE)

Med Image Comput Comput Assist Interv. 2012;15(Pt 1):495-503. doi: 10.1007/978-3-642-33415-3_61.

Abstract

A new data structure is presented for geometrically modeling multi-objects. The model can exhibit elastic and fluid-like behavior to enable interpretability between tasks that require both deformable registration and active contour segmentation. The data structure consists of a label mask, distance field, and springls (a constellation of disconnected triangles). The representation has sub-voxel precision, is parametric, re-meshes, tracks point correspondences, and guarantees no self-intersections, air-gaps, or overlaps between adjacent structures. In this work, we show how to apply existing registration algorithms and active contour segmentation to the data structure; and as a demonstration, the data structure is used to segment cortical and subcortical structures (74 total) in the human brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Brain / anatomy & histology
  • Brain / pathology*
  • Brain Mapping / methods
  • Computer Simulation
  • Databases, Factual
  • Elasticity
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Models, Statistical
  • Pattern Recognition, Automated
  • Programming Languages
  • Reproducibility of Results
  • Software
  • Surface Properties