Synthesis of (-)-neothiobinupharidine

J Am Chem Soc. 2013 Jan 30;135(4):1209-12. doi: 10.1021/ja310778t. Epub 2013 Jan 11.

Abstract

An eight step, asymmetric synthesis of a dimeric thiaspirane nuphar alkaloid from 3-methyl-2-cyclo-pentenone is reported. The brevity of the route relies on a useful procedure for tandem reductive allylation of cyclopentenones, as well as the minimization of redox manipulations and other functional group interconversions. The distribution of products that arise from spontaneous dimerization points to a more complex biosynthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry
  • Furans / chemical synthesis*
  • Furans / chemistry
  • Models, Molecular
  • Molecular Conformation
  • Spiro Compounds / chemical synthesis*
  • Spiro Compounds / chemistry

Substances

  • Alkaloids
  • Furans
  • Spiro Compounds
  • neothiobinupharidine