Palladium-catalyzed ortho-CH-bond oxygenation of aromatic ketones

Org Lett. 2013 Jan 18;15(2):270-3. doi: 10.1021/ol303088z. Epub 2013 Jan 9.

Abstract

A palladium-catalyzed C((sp2))-H bond oxygenation reaction is described. This protocol represents the first example of a C-H bond cleavage/C-O bond formation sequence, by employing a ketone moiety as the directing group. With this new catalytic method, a variety of ortho-acylphenols can be easily accessed from arylketones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Combinatorial Chemistry Techniques
  • Ketones / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Palladium / chemistry*
  • Phenols / chemical synthesis
  • Phenols / chemistry
  • Stereoisomerism

Substances

  • Ketones
  • Phenols
  • Palladium