Comparative study of pelvic floor biofeedback training and tolterodine for treatment of detrusor after-contraction in posturination dribbling in children

J Int Med Res. 2012;40(6):2305-10. doi: 10.1177/030006051204000628.

Abstract

Objectives: To investigate the prevalence of detrusor after-contraction (DA-C) in children with posturination dribbling, and compare the outcomes of pharmacological treatment and pelvic floor biofeedback training.

Methods: Children with posturination dribbling underwent urodynamic studies. Patients with DA-C were randomly allocated to one of two groups: pelvic floor biofeedback training or 1 mg tolterodine, orally, twice daily. Treatment was continued for 12 weeks.

Results: The study included 45 children. DA-C was present in 39 patients (86.6%), 30 (76.9%) of whom also exhibited detrusor overactivity. Pelvic floor biofeedback training resulted in a significantly better response than tolterodine, in terms of reduction in the number of posturination dribbling events in the month after completion of treatment.

Conclusions: DA-C is closely associated with posturination dribbling in children. Pelvic floor biofeedback training should be considered the initial treatment option in these patients.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Benzhydryl Compounds / therapeutic use*
  • Biofeedback, Psychology*
  • Child
  • Cresols / therapeutic use*
  • Female
  • Humans
  • Male
  • Muscarinic Antagonists / therapeutic use*
  • Muscle Contraction
  • Muscle, Smooth / physiopathology
  • Pelvic Floor
  • Phenylpropanolamine / therapeutic use*
  • Tolterodine Tartrate
  • Urinary Bladder
  • Urinary Bladder, Overactive / drug therapy*
  • Urinary Incontinence / drug therapy*
  • Urinary Incontinence / etiology
  • Urodynamics

Substances

  • Benzhydryl Compounds
  • Cresols
  • Muscarinic Antagonists
  • Phenylpropanolamine
  • Tolterodine Tartrate