Factors affecting response of chemotherapy in women with ovarian cancer

Eur J Gynaecol Oncol. 2012;33(6):644-7.

Abstract

Chemotherapy plays an important role in the treatment of ovarian cancer. Patients' response to chemotherapy is determined by a variety of acknowledged factors, but one might expect that many of them are yet to be described. The aim of this paper was to present the most essential yet still to be generally assessed in clinical practice, factors, which include: E-cadhedrin, hypoxia inducible factor alpha, survivin, COX-2, clusterin, BRCA1 protein, TP53 protein, YY1 protein, multidrug resistance protein, and interleukin-8.

Publication types

  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology
  • Cadherins / analysis
  • Cadherins / physiology
  • Clusterin / analysis
  • Cyclooxygenase 2 / analysis
  • Cyclooxygenase 2 / physiology
  • Female
  • Genes, BRCA1
  • Genes, p53
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / analysis
  • Hypoxia-Inducible Factor 1, alpha Subunit / physiology
  • Inhibitor of Apoptosis Proteins / analysis
  • Inhibitor of Apoptosis Proteins / physiology
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / genetics
  • Survivin

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • BIRC5 protein, human
  • CLU protein, human
  • Cadherins
  • Clusterin
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Inhibitor of Apoptosis Proteins
  • Survivin
  • Cyclooxygenase 2