The impact of trisomy 21 on early human hematopoiesis

Cell Cycle. 2013 Feb 15;12(4):533-4. doi: 10.4161/cc.23667. Epub 2013 Jan 23.
No abstract available

Keywords: Down syndrome; acute megakaryoblastic leukemia; fetal liver; hematopoiesis; neonatal leukemia; transient abnormal myelopoiesis; trisomy 21.

Publication types

  • Editorial

MeSH terms

  • Bone Marrow / growth & development
  • Bone Marrow / metabolism
  • Bone Marrow / pathology
  • Cellular Microenvironment
  • Down Syndrome / blood*
  • Down Syndrome / complications
  • Down Syndrome / genetics*
  • Down Syndrome / pathology
  • Fetus
  • GATA1 Transcription Factor / genetics
  • Hematopoiesis / genetics*
  • Humans
  • Leukemia, Megakaryoblastic, Acute / complications
  • Leukemia, Megakaryoblastic, Acute / genetics*
  • Leukemia, Megakaryoblastic, Acute / pathology
  • Leukemoid Reaction / complications
  • Leukemoid Reaction / genetics*
  • Leukemoid Reaction / pathology
  • Mutation
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology

Substances

  • GATA1 Transcription Factor
  • GATA1 protein, human

Supplementary concepts

  • Myeloproliferative Syndrome, Transient