Grating-based darkfield imaging of human breast tissue

Z Med Phys. 2013 Sep;23(3):228-35. doi: 10.1016/j.zemedi.2013.01.001. Epub 2013 Feb 4.

Abstract

Mastectomy specimens were investigated using a Talbot-Lau X-ray imaging set-up. Significant structures in the darkfield were observed, which revealed considerably higher contrast than those observed in digital mammography. Comparison with the histomorphometric image proofs that the darkfield signal correlates with a tumor region containing small calcification grains of 3 to 30μm size.

Keywords: Brustkrebs; Dunkelfeldbildgebung; Mammographie; Mikrokalzifikation; Röntgenbildgebung; Talbot-Lau; X-ray imaging; breast cancer; darkfield imaging; mammography; microcalcification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / etiology
  • Cadaver
  • Calcinosis / complications
  • Calcinosis / diagnostic imaging*
  • Equipment Design
  • Equipment Failure Analysis
  • Feasibility Studies
  • Humans
  • Interferometry / instrumentation
  • Interferometry / methods*
  • Mammography / instrumentation
  • Mammography / methods
  • Refractometry / instrumentation
  • Refractometry / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / instrumentation
  • Tomography, X-Ray Computed / methods*
  • X-Ray Diffraction / instrumentation
  • X-Ray Diffraction / methods*