Clinical study of urinary excretion of Ga-67

Clin Nucl Med. 1990 Apr;15(4):260-2. doi: 10.1097/00003072-199004000-00012.

Abstract

Ga-67 urinary excretion was examined in 59 patients. The 72-hour urinary excretion rate ranged from 4.3 to 67.8% of the injected dose. Within the first 24 hours, 60.9% of the 72-hour urinary excretion was excreted. There was no significant difference in the Ga-67 urinary excretion rate between males and females, nor between the Ga-67 positive and negative cases. A significant negative correlation was found between the 72-hour Ga-67 urinary excretion rate and the unsaturated iron binding capacity. Notably, four patients with hyperferremia, which was considered secondary to leukemia and/or chemotherapy or liver cirrhosis, excreted more than 46.8% of Ga-67 within 72 hours. A significant negative correlation was also found between the 72-hour Ga-67 urinary excretion rate and age. Urinary excretion of Ga-67 may be related to the glomerular filtration rate, which decreases with age.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Female
  • Gallium Radioisotopes / urine*
  • Humans
  • Iron / metabolism
  • Male
  • Middle Aged
  • Neoplasms / diagnostic imaging*
  • Neoplasms / urine
  • Radionuclide Imaging
  • Transferrin / metabolism

Substances

  • Gallium Radioisotopes
  • Transferrin
  • Iron