Pseudo-observations for competing risks with covariate dependent censoring

Lifetime Data Anal. 2014 Apr;20(2):303-15. doi: 10.1007/s10985-013-9247-7. Epub 2013 Feb 22.

Abstract

Regression analysis for competing risks data can be based on generalized estimating equations. For the case with right censored data, pseudo-values were proposed to solve the estimating equations. In this article we investigate robustness of the pseudo-values against violation of the assumption that the probability of not being lost to follow-up (un-censored) is independent of the covariates. Modified pseudo-values are proposed which rely on a correctly specified regression model for the censoring times. Bias and efficiency of these methods are compared in a simulation study. Further illustration of the differences is obtained in an application to bone marrow transplantation data and a corresponding sensitivity analysis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bias
  • Bone Marrow Transplantation
  • Computer Simulation
  • Humans
  • Leukemia / therapy
  • Life Tables
  • Models, Statistical
  • Recurrence
  • Regression Analysis*
  • Risk*
  • Survival Analysis