Three new nor-dammarane triterpenoids from Dysoxylum hainanense with particular cytotoxicity against glioma cell line

Arch Pharm Res. 2013 Mar;36(3):322-6. doi: 10.1007/s12272-013-0030-9. Epub 2013 Feb 22.

Abstract

Three new nor-dammarane triterpenoids, 12β-O-acetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (1), 12β,28-O-diacetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (2), 12β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanran (3), together with one known compound, 12β-O-acetyl-15α,28-dihydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 95 % EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (BGC-823, U251, HepG2 and SGC-7901). All the three nor-dammarane triterpenoids exhibited particular significant cytotoxic activities against glioma cell line.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cell Line, Tumor
  • Cytotoxins / chemistry*
  • Cytotoxins / isolation & purification
  • Cytotoxins / therapeutic use
  • Dammaranes
  • Glioma* / drug therapy
  • Hep G2 Cells
  • Humans
  • Meliaceae*
  • Plant Bark*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / therapeutic use

Substances

  • Antineoplastic Agents, Phytogenic
  • Cytotoxins
  • Triterpenes