Monte Carlo lookup table-based inverse model for extracting optical properties from tissue-simulating phantoms using diffuse reflectance spectroscopy

J Biomed Opt. 2013 Mar;18(3):037003. doi: 10.1117/1.JBO.18.3.037003.

Abstract

We present a Monte Carlo lookup table (MCLUT)-based inverse model for extracting optical properties from tissue-simulating phantoms. This model is valid for close source-detector separation and highly absorbing tissues. The MCLUT is based entirely on Monte Carlo simulation, which was implemented using a graphics processing unit. We used tissue-simulating phantoms to determine the accuracy of the MCLUT inverse model. Our results show strong agreement between extracted and expected optical properties, with errors rate of 1.74% for extracted reduced scattering values, 0.74% for extracted absorption values, and 2.42% for extracted hemoglobin concentration values.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Absorption
  • Computer Simulation
  • Hemoglobins / chemistry
  • Humans
  • Image Processing, Computer-Assisted
  • Models, Biological*
  • Monte Carlo Method*
  • Phantoms, Imaging*
  • Reproducibility of Results
  • Spectrum Analysis / instrumentation
  • Spectrum Analysis / methods*

Substances

  • Hemoglobins