The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis

J Neuroimmunol. 2013 Apr 15;257(1-2):53-8. doi: 10.1016/j.jneuroim.2013.02.002. Epub 2013 Mar 7.

Abstract

Chemokine receptors (CCRs) play important roles in the pathogenesis of immune-mediated diseases, as well as in normal immune response. We examined the role of CCR6 and CCR4 in experimental autoimmune encephalomyelitis (EAE) by using CCR6(-/-)CCR4(-/-) double knockout (DKO) and single knockout mice. DKO mice developed less severe EAE and presented repressed recall response in the induction phase, especially in the activity of T helper 17 (Th17) cells. CCR6 expression in central nervous system (CNS)-infiltrated cells was diminished in DKO. Our results suggest that CCR6 and CCR4 were involved in a more rapid progression of EAE and that their regulation might be a therapeutic target of human inflammatory demyelinating diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Progression
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Encephalomyelitis, Autoimmune, Experimental / metabolism*
  • Encephalomyelitis, Autoimmune, Experimental / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, CCR4 / deficiency
  • Receptors, CCR4 / genetics
  • Receptors, CCR4 / physiology*
  • Receptors, CCR6 / deficiency
  • Receptors, CCR6 / genetics
  • Receptors, CCR6 / physiology*
  • Th17 Cells / immunology
  • Th17 Cells / metabolism

Substances

  • CCR6 protein, mouse
  • Ccr4 protein, mouse
  • Receptors, CCR4
  • Receptors, CCR6