Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor

Pinchas Tsukerman; Jonatan Enk; Ofer Mandelboim

doi:10.4161/onci.22245

Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor

Oncoimmunology. 2013 Jan 1;2(1):e22245. doi: 10.4161/onci.22245.

Authors

Pinchas Tsukerman¹, Jonatan Enk, Ofer Mandelboim

Affiliation

¹ Lautenberg Center for General and Tumor Immunology; The Hebrew University; The BioMedical Research Institute; Hadassah Medical School; Jerusalem, Israel.

Abstract

Metastases are responsible for more than 90% of cancer-related deaths. We have recently reported that miR-10b inhibits the expression of MICB, a stress-induced ligand of the activating natural killer (NK)-cell receptor NKG2D. Here, we discuss our findings, which link metastasis formation to immune evasion.