A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction

Org Biomol Chem. 2013 Apr 28;11(16):2574-7. doi: 10.1039/c3ob40157j.

Abstract

A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemical synthesis
  • Alkynes / chemistry
  • Catalysis
  • Copper / chemistry
  • Halogenation
  • Isomerism
  • Palladium / chemistry
  • Propanols / chemical synthesis
  • Propanols / chemistry
  • Pyridazines / chemical synthesis*
  • Pyridazines / chemistry
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry

Substances

  • Alkynes
  • Propanols
  • Pyridazines
  • Pyrroles
  • Palladium
  • Copper
  • propargyl alcohol