Treatment of aortic field infections is challenging and usually involves removal of the infected segment with re-vascularization of the distal arterial tree with infection-resistant graft material or via an extra-anatomical route. We present three cases of arterial infection treated successfully using cryopreserved superficial femoral artery homografts as aortoiliac substitutes. This new approach is a potential alternative to other in situ re-vascularization techniques.