Oxidative para-triflation of acetanilides

Org Lett. 2013 Apr 5;15(7):1764-7. doi: 10.1021/ol400604e. Epub 2013 Mar 27.

Abstract

Direct triflation of acetanilide derivatives with silver triflate has been accomplished under mild iodine(III)-mediated oxidative conditions. The reaction shows excellent regioselectivity for the para position and tolerates a range of ortho and meta substituents on the aromatic ring. This method is also compatible with the preparation of arylnonaflates in synthetically useful yields.