Abstract
This functional magnetic resonance imaging study shows that children and adults with bipolar disorder (BD), compared with healthy subjects, exhibit impaired memory for emotional faces and abnormal fusiform activation during encoding. Fusiform activation abnormalities in BD were correlated with mania severity and may therefore represent a trait and state BD biomarker.
Published by Elsevier Ireland Ltd.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Adolescent
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Adult
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Age Factors
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Analysis of Variance
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Bipolar Disorder / complications*
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Bipolar Disorder / pathology*
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Brain / blood supply*
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Brain / growth & development
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Brain / pathology*
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Child
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Cognition Disorders / etiology*
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Female
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Humans
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Image Processing, Computer-Assisted
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Linear Models
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Magnetic Resonance Imaging
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Male
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Memory Disorders / etiology*
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Middle Aged
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Neuropsychological Tests
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Oxygen
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Psychiatric Status Rating Scales
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Young Adult