Microfluidic space-domain time-resolved emission spectroscopy of terbium(III) and europium(III) chelates with pyridine-2,6-dicarboxylate

Anal Chem. 2013 May 7;85(9):4567-77. doi: 10.1021/ac400200x. Epub 2013 Apr 17.

Abstract

This article describes the utilization of laminar microflows for time-resolved emission measurements with steady-state excitation and detection. Passing a laminar flow through a short illuminated section of a microchannel provided a means for pulsed-like photoexcitation of the moieties carried by the fluid. Imaging the microchannel flows carrying thus photoexcited chelates of lanthanide ions allowed us to extract their excited-state lifetimes from the spatial distribution of the changes in the emission intensity. The lifetime values obtained using this space-domain approach agreed well with the lifetimes from time-domain measurements. This validated space-domain microfluidic approach reveals a means for miniaturization of time-resolved emission spectroscopy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry*
  • Europium / chemistry*
  • Microfluidic Analytical Techniques* / instrumentation
  • Microscopy, Fluorescence
  • Picolinic Acids / chemistry*
  • Terbium / chemistry*
  • Time Factors

Substances

  • Chelating Agents
  • Picolinic Acids
  • Terbium
  • Europium
  • dipicolinic acid